The San Francisco 49ers will get quarterback Brock Purdy and one of his top targets, wide receiver Ricky Pearsall, back from injury on Sunday against the Arizona Cardinals, after both missed six consecutive games.

Key 49ers and Cardinals offensive stars face critical tests as both teams battle to regain momentum and establish dominance.

The 49ers do not have a competent pass defense. They possess good safety coverage, but their cornerbacks are the defense’s weak link. The Cardinals need to throw the 8–12-yard passes and then insert some 20-yard plays.

See who's in and who's out for the Week 11 matchup between the San Francisco 49ers and Arizona Cardinals on November 16, 2025.

The 49ers are arguably the worst team the Cardinals will have faced since Jacoby Brissett took over as quarterback. In the last four weeks, the Cardinals have played the Indianapolis Colts, Green Bay Packers, Dallas Cowboys, and Seattle Seahawks, with three of those games being on the road.

Find out how to watch San Francisco 49ers vs. Arizona Cardinals live streaming online, plus TV channel and game info for this week 11 NFL matchup.

NFC West standings: Rams, Seahawks strengthen records with wins over 49ers, Cardinals originally appeared on The Sporting News. Add The Sporting News as a Preferred Source by clicking here. The NFC West has proven to be the most difficult division in the NFL this year with three teams in playoff positioning entering Sunday.

Nov 9, 2025; Santa Clara, California, USA; San Francisco 49ers running back Christian McCaffrey (23) walks on the field prior to the game against the Los Angeles Rams at Levi's Stadium. Mandatory Credit: Cary Edmondson-Imagn Images / Cary Edmondson-Imagn Images ARIZONA -- The Arizona Cardinals' next test doesn't get any easier to pass.