2025 NFL Wild Card prediction, odds, line, spread, time: Broncos vs. Bills picks, bets by expert on 25-7 roll
Buffalo is an 8.5-point favorite in the latest Broncos vs. Bills odds, while the over/under for total points scored is 47. Before you make any Broncos vs. Bills picks, make sure to check out the NFL predictions and betting advice from the SportsLine expert Matt Severance,
Buffalo Bills have one massive X-Factor against Denver Broncos
Bills wide receivers Mack Hollins, Amari Cooper and Khalil Shakir run off the field during first half action of their home game against the San Francisco 49ers in Orchard Park on Dec. 1, 2024. / Tina MacIntyre-Yee/Democrat and Chronicle / USA TODAY NETWORK via Imagn Images
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Head coach Sean McDermott and the Bills host a Denver Broncos team in the Wild Card round that is led by rookie quarterback ...
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