A study led by researchers at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has identified a mitochondrial "checkpoint" that enables dendritic cells to efficiently activate T ...

Superantigens are a class of microbial proteins that bypass conventional antigen processing by directly bridging major histocompatibility complex class II molecules on antigen-presenting cells with ...

A new mRNA strategy reprogrammed immune cells to strengthen vaccine-induced T-cell activity. The approach enhanced immune response in both cancer and infectious disease vaccine models.

Bristol Myers Squibb hasn’t had much luck with its efforts to develop cancer treatments called T cell engagers. But the pharmaceutical company isn’t done pursuing this type of targeted cancer therapy, ...

Why do immune cells that are supposed to eliminate viruses suddenly turn against our own body? There are instances where killer T cells—which are meant to precisely remove virus-infected ...

Durable reprogramming of human T cells may now be possible thanks to a new technique based on the CRISPRoff and CRISPRon methodology. Researchers from the Arc Institute, Gladstone Institutes, and the ...

New approach recruits the body’s immune system to attack glioblastoma while reducing treatment-related toxicity.

(A) CuN is formed by self-assembly of Cu²⁺ and NLG919 via Cu-N coordination bonds, with chemotherapeutic agents (e.g., β-lapachone) encapsulated through hydrophobic interactions. (B) Lap@CuN passively ...

Researchers at the Keck School of Medicine of University of Southern California (USC) have developed a new type of chimeric antigen receptor (CAR) T cell that elicits a more controlled immune response ...