In a recent study published in the Proceedings of the National Academy of Sciences, researchers assessed the capability of two small molecules of disintegrating alpha-synuclein fibrils. Parkinson's ...

Alpha-synuclein is a small presynaptic protein that under physiological conditions exists predominantly in a soluble, monomeric state and plays roles in vesicle trafficking and neurotransmitter ...

After Alzheimer's, Parkinson's is the most common neurodegenerative disease in the world. More than six million people worldwide suffer from it. In this disease, alpha-synuclein proteins form ...

There’s a new twist to the Lewy body story. In a manuscript uploaded July 12 to bioRXiv, scientists led by Sjors Scheres and Michel Goedert at the Medical Research Council Laboratory of Molecular ...

Parkinson's disease (PD) and Lewy body dementia (LBD) are incurable and progressive neurodegenerative disorders, with some overlapping symptoms. An estimated 10 million people worldwide live with PD, ...

The iRS platform offers a breakthrough in early detection of Alzheimer's and Parkinson's through precise measurement of ...

Parkinson's disease (PD) and Lewy body dementia (LBD) are incurable and progressive neurodegenerative disorders, with some overlapping symptoms. An estimated 10 million people worldwide live with PD, ...

Fibrils of α-synuclein may be the common denominator among the synucleinopathies, but they do not all map to the same blueprint. Fibrils from people who have multiple system atrophy fold differently ...

Scientists have carried out an extensive study of a newly discovered mutation that can uncover new insights into the molecular basis of pathology formation in a family of disorders that includes Lewy ...

The so-called isolated REM-sleep behavior disorder is a condition that can provide an indication of Parkinson's disease well in advance. A research team headed by Professor Dr Erdem Gültekin Tamgüney ...

Images taken with an atomic force microscope show alpha-synuclein in the form of fibrils (left). The fibrils are a few hundred nanometers to one micrometer long. When the protein is placed in a ...