Nature

Development of deaminase-free T-to-S base editor and C-to-G base editor by engineered human uracil DNA glycosylase

Base editors enable single-nucleotide edits with high precision and efficiency, providing powerful tools for the fields of life science and medicine 1,2. Two categories of DNA base editors, ...
Nature

Base editors for simultaneous introduction of C-to-T and A-to-G mutations

We describe base editors that combine both cytosine and adenine base-editing functions. A codon-optimized fusion of the cytosine deaminase PmCDA1, the adenosine deaminase TadA and a Cas9 nickase ...