Docking experiments showed that c-di-GMP would not bind the CLP of other isoforms, such as HCN1 and HCN2 (Supplementary Fig. 1b). Although the CLP binding pocket has a high sequence homology within ...

In the molecular-level world of ion channels—passageways through membranes that carry signals in a cell's environment and allow it to respond—researchers have debated about the role of a small piece ...