Case-control studies remain a cornerstone of observational epidemiology, enabling efficient investigation of associations between exposures and rare or costly outcomes. At their heart lies the careful ...

Bhattacharya attacked study's test-negative design, a staple of vaccine effectiveness rese ...

Observational study designs like cohort, case-control, and cross-sectional are the backbone of epidemiology, but each comes with unique strengths, limitations, and bias risks. Understanding these ...

As biomarker studies employ increasingly complex and expensive genomics and other correlative methods, it is increasingly important to rigorously design these studies and analyze the downstream ...

The US Food and Drug Administration (FDA) recently highlighted three case studies showing how sponsors can incorporate innovative study designs in their clinical trials using the agency’s Complex ...

Whereas cardiovascular disease-related mortality has declined in most developed countries, its known prevalence is increasing worldwide, although few data on the causes of heart disease in the ...