Within molecular biology, few regulatory proteins have attracted as much sustained attention as P21, a cyclin-dependent ...

Cellular senescence is a process in which the cell cycle becomes permanently arrested, thereby inhibiting cell division, proliferation and growth. Various cellular stresses, such as DNA damage, ...

Researchers have defined a new genetic disease caused by a mutation in the IVNS1ABP gene. The condition marks a rare ...

Scientists at Sanford Burnham Prebys Medical Discovery Institute and an international team of collaborators have defined a ...

Cellular senescence, a state characterized by stable cell cycle arrest, has emerged as a critical process in maintaining tissue homeostasis by limiting the ...

This Collection supports and amplifies research related to SDG 3. This is a joint Collection across npj Aging, Nature Aging, Nature Metabolism, Nature Cell Biology and Scientific Reports. Please see ...

Aging cells secrete substances known to promote the growth of cancer cells. The development of drugs that can selectively kill these cells or inhibit the secretion of substances is ongoing. The latest ...

Senescence, aging, and age-related diseases represent complex biological phenomena with significant impacts on human health, and metabolism and metabolomics play pivotal roles in understanding their ...

Scientists at Sanford Burnham Prebys Medical Discovery Institute and an international team of collaborators have defined a new genetic disease marked by premature aging and deficits in brain function.

A central question in molecular biology is how cells protect their chromosomes from damage during repeated cell division. At ...

Cellular senescence—an irreversible cell-cycle arrest coupled with the production of pro-inflammatory secretions known as SASP—is now viewed as a central driver of musculoskeletal aging. Accumulation ...