Lead programme based on a first--in--class small--molecule E6AP ubiquitin ligase inhibition strategy for the treatment of HPV--positive head and neck cancer -- Programme has demonstrated strong in ...

Scientists from The University of Manchester have uncovered a more efficient and sustainable way to make peptide-based medicines, showing promising effectiveness in combating cancers. Image Credit: ...

Their findings, published in a Cell Reports paper titled “Palmitoylation and PDE6δ regulate membrane-compartment-specific substrate ubiquitylation and degradation,” have implications for developing ...

Over the past decade, however, a wave of technological advances has begun to expand the druggable proteome. These include covalent inhibitors (such as sotorasib), chemical proteomics, and AI-enabled ...

University researchers developed a new ligase, an enzyme that joins together strands of DNA or RNA and has applications in biotechnology and diagnostics, as described in an Oct. 7 paper in RNA Biology ...

Researchers at Baylor College of Medicine and the Broad Institute of MIT and Harvard and clinicians at Washington University in St. Louis have identified biological markers in triple negative breast ...

Researchers have produced the first molecular images of an enzyme that controls proteins to signal and communicate with each other in human cells. The discovery could help to solve the mystery cause ...