Nature

Osteocytes regulate bone anabolic response to mechanical loading in male mice via activation of integrin α5

Physical mechanical stimulation can maintain and even increase bone mass. Here, we report an important role of osteocytic integrin α5 in regulating the anabolic response of bone to mechanical loading ...
Nature

Mechanical signals as anabolic agents in bone

Aging and a sedentary lifestyle conspire to reduce bone quantity and quality, decrease muscle mass and strength, and undermine postural stability, culminating in an elevated risk of skeletal fracture.
Phys.org

Study finds that gravity, 'mechanical loading' are key to cartilage development

Mechanical loading, or forces that stimulate cellular growth for development, is required for creating cartilage that is then turned to bone; however, little is known about cartilage development in ...
BMJ

Mechanotherapy: how physical therapists’ prescription of exercise promotes tissue repair

Professor K M Khan, Centre for Hip Health and Mobility and Department of Family Practice, University of British Columbia, Vancouver, Canada; karim.khan{at}ubc.ca Mechanotransduction is the ...
SpaceNews

Study finds that gravity, ‘mechanical loading’ are key to cartilage development

Mechanical loading, or forces that stimulate cellular growth for development, is required for creating cartilage that is then turned to bone; however, little is known about cartilage development in ...
Science Daily

Gravity, 'mechanical loading' are key to cartilage development

Mechanical loading is required for creating cartilage that is then turned to bone; however, little is known about cartilage development in the absence of gravity. Now, bioengineers have determined ...