A single dose of a cancer-causing chemical, given to mice at 15 days of age, produced strikingly different tumors depending ...

From the time we are conceived and through old age, genetic mutations accumulate in all our tissues, eluding the body's typically efficient DNA repair machinery and potentially affecting our health ...

A new study suggests that DNA mutations may limit human life span to 146–194 years, even under favorable conditions. The ...

A study has found that even if all causes of aging, such as telomere shortening, are eliminated, only half of people would ...

Smoking is one of the biggest preventable causes of lung cancer, but an interesting question remains: if tobacco smoke ...

New research published in Nature Communications into hidden mutations in mitochondrial DNA has uncovered how high mutational levels coincide with later life and link to aging markers. Mitochondria are ...

Mutations accumulated in mitochondrial DNA associated with aging were earlier believed to cause aging by decreasing the energy-producing function (mitochondrial respiratory function). In this study, ...

Cancer cells rely on powerful genetic switches to keep growth genes running at full speed, but that intense activity can damage their own DNA. The resulting breaks are repeatedly repaired, sometimes ...

In a step toward treating mitochondrial diseases, researchers in the Netherlands have successfully edited harmful mutations in mitochondrial DNA using a genetic tool known as a base editor. The ...

ALS-causing NEK1 gene mutations disrupt cellular protein production machinery. Truncated NEK1 protein accumulates in the nucleolus, impairing ribosome biogenesis. This disruption leads to cell death ...