Trametinib, a mitogen-activated protein kinase (MEK) inhibitor, reduces mortality and morbidity in children with severe hypertrophic cardiomyopathy (HCM) caused by pathogenic variants in the RAS/MAPK ...
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What ATTR-CM means for family members: Genetics, testing, and tough conversation
Medically reviewed by Jeffrey S. Lander, MD Key Takeaways There is a hereditary form of transthyretin amyloid cardiomyopathy (ATTR-CM) caused when a mutated gene is passed from parent to child.Having ...
An analysis of two large cohort studies finds that carriers of disease-causing variants within genes for three ...
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TRIM63 identified as key gene in common heart disease, unlocking potential for earlier diagnosis
An Israeli study has identified TRIM63 as a significant genetic contributor to hypertrophic cardiomyopathy (HCM)—the most common hereditary heart disease worldwide. The findings, published in ...
Trametinib, a mitogen-activated protein kinase (MEK) inhibitor, reduces mortality and morbidity in children with severe hypertrophic cardiomyopathy (HCM) caused by pathogenic variants in the RAS/MAPK ...
A groundbreaking discovery from Israeli scientists is changing what doctors know about inherited heart disease. Researchers have pinpointed a gene, TRIM63, as a major contributor to hypertrophic ...
A pioneering Israeli study has identified TRIM63 as a significant genetic contributor to hypertrophic cardiomyopathy (HCM)—the most common hereditary heart disease worldwide. The findings, published ...
Arrhythmogenic cardiomyopathy (ACM) is a severe genetic cardiac disorder caused by mutations in some desmosomal genes. The most frequently affected gene in patients with ACM is PKP2, the loss of which ...
COVID-19 exacerbated adverse outcomes in peripartum cardiomyopathy, increasing myocardial infarction, intensive care unit admissions, and mortality rates. Hypertrophic cardiomyopathy patients ...
Some patients with diabetes develop a serious condition known as diabetic cardiomyopathy, which is slow and cannot be directly attributed to hypertension or other cardiovascular disorders. This often ...
Please provide your email address to receive an email when new articles are posted on . A serum protein panel predicted risk for cardiac toxicity among childhood cancer survivors exposed to ...
Early treatment with the aldosterone antagonist eplerenone (Inspra, Pfizer) plus an angiotensin-converting enzyme inhibitor (ACEI) or angiotensin-receptor blocker (ARB) slows the progression of ...
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