A cluster of recent studies has sharpened the scientific picture of how T cells switch on, tracking the molecular signals ...

Efficient T-cell engineering is crucial for the success of CAR T-cell therapy research, but it requires multiple labor-intensive steps, including T-cell isolation, activation, and transduction.

T cell activation—the process by which these key immune defenders recognize threats and mobilize against them—depends on ...

The orchestration of T cell activation is central to immune defence and self-tolerance. Recent advances have revealed that T cells integrate signals from their antigen receptors alongside a network of ...

A new AI tool that models how variations in peptides change T cell receptor binding could help design immunotherapies with fewer off-target effects. Protein complexes that adorn the surface of T cells ...

SMART control of CAR T cells is advancing cancer immunotherapy by improving precision, safety, and adaptability. Why Smart ...

Lymph nodes, considered the command centers of our immune system, often get swollen and stiff when fighting infection. Now, a UC Berkeley-led team of researchers has discovered that this mechanical ...

When a virus enters the lungs, the immune system has to react fast. The lung maintains its own community of immune cells ...

CD8 + cytotoxic T lymphocytes (CTLs) serve as central effectors in cancer immunotherapy by directly eliminating tumor cells. However, current clinical therapies face significant limitations. These ...

Lymph nodes are key control centers in the immune system and play an important role in defending the body against infections ...

A tumor “don’t‑eat‑me” shield also hides pro‑immune danger signals; new antibodies that unmask this hidden cue could make cancers more vulnerable to immune attack.