Microbial CRISPR–Cas systems have been engineered to manipulate target DNA or RNA sequences in human cells. As these systems use a complementary guide RNA (gRNA) to find their target sequence, they ...

Instead of pulling cells out of the body, editing them, and putting them back in, scientists have now found a way to send CRISPR tools directly to specific cells inside living animals. By wrapping ...

Tissue or organ targeted drug delivery holds the promise to increase the drug efficacy and reduce side effects. Unlike soft tissues, bone tissue possesses some specificity in cellular components, ...

The study, published in the Proceedings of the National Academy of Sciences, highlights compelling features of the therapy-delivering system with respect to size, targetability, encapsulation ...