Biotech companies can skyrocket in a short period because of excellent clinical or regulatory progress. And if we take the word of Wall Street analysts, some of them will do precisely that in the next year.

U.S. stock indexes are drifting Wednesday after a four-day losing streak knocked Wall Street off its all-time high and threw some of its brightest stars into reverse. The S&P 500 was down 0.1% in afternoon trading.

Some of Wall Street’s brightest stars lost more of their shine Tuesday after another report said U.S. households are getting more pessimistic about the economy. The S&P 500 fell 0.5% and had been down as much as 1.