When Kerry Washington announced Demi Moore as the Golden Globes winner for Best Comedy/Musical Actress on Sunday night, the crowd reacted in surprise jubilation — and that was before The Substance star brought the house down with the best acceptance speech of the night.

Demi Moore landed the first acting award of her career — yes, career — after taking home the Golden Globe for best actress in a motion picture, musical or comedy. She won for her go-for-broke performance as an aging celebrity in the body horror satire “The Substance.

Moore beat out Mikey Madison in Anora, Cynthia Erivo for Wicked, Zendaya for Challengers, Amy Adams for Nightbitch, and Karla Sofia Gascon for Emilia Perez to win the Globe, This marked the first win of the night for The Substance.