Donovan Mitchell scores a season-high 46 points as the Cleveland Cavaliers defeated the Philadelphia 76ers 132-121.

The 76ers (5-2) are playing their second game in a back to back against the Cavs. Rookie V.J. Edgecombe has come out swinging early as a heavy Rookie of the Year candidate. Along with him in the backcourt, Tyrese Maxey has been on fire, averaging 34.3 points per game.

Darius Garland is back. The Cavaliers have activated their All-Star point guard for Wednesday's game against the Philadelphia 76ers. He'll make his season debut after missing Cleveland's first seven games.

Darius Garland was back in his happy place on Wednesday night. The Cleveland Cavaliers point guard made his season debut against the Philadelphia 76ers and was back on the floor directing the offense.

The Philadelphia 76ers visit the Cleveland Cavaliers to play the second leg of the first of three back-to-backs in November.

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Here is the full injury report for Joel Embiid and the Philadelphia 76ers as they take on the Cleveland Cavaliers to finish their road trip.

Donovan Mitchell is cleared to play for the Cleveland Cavaliers against the Philadelphia 76ers on November 5, 2025, following a left hamstring injury. His return, after a 37-point performance, provides a significant boost as Cleveland aims to build momentum.

The Cleveland Cavaliers defeated the Philadelphia 76ers with a 132–121 victory on Wednesday at home behind 46 points from Donovan Mitchell on 71 percent shooting from the field.