The San Francisco 49ers face their division rivals, the Arizona Cardinals, at State Farm Stadium in Glendale, Arizona on Sunday, Nov. 16 at 1:05 p.m.

The 49ers are arguably the worst team the Cardinals will have faced since Jacoby Brissett took over as quarterback. In the last four weeks, the Cardinals have played the Indianapolis Colts, Green Bay Packers, Dallas Cowboys, and Seattle Seahawks, with three of those games being on the road.

Before the 49ers and Cardinals face off in their NFC West battle, check out these bold predictions. Can Arizona pull off the upset?

The San Francisco 49ers have started out 6-4, and now they'll take on the Arizona Cardinals. Here's how to tell if the game will be on TV near you.

USA Today's NFL experts make their picks for a Week 11 showdown between the Arizona Cardinals and San Francisco 49ers

In Week 11, the Arizona Cardinals host the San Francisco 49ers, but they will be without wide receiver Marvin Harrison Jr., who will miss the game after undergoing surgery for appendicitis.

ARIZONA -- The Arizona Cardinals are shorthanded entering their Week 11 matchup against the San Francisco 49ers, and it appears only one man can save them. Star tight end Trey McBride, awarded for his play with a massive contract extension this past offseason, has excelled to even newer heights in 2025.

Find out how to watch San Francisco 49ers vs. Arizona Cardinals live streaming online, plus TV channel and game info for this week 11 NFL matchup.