Cardinals head coach Jonathan Gannon reacts to the 49ers’ switch back to Brock Purdy at quarterback, offering insight on why San Francisco’s offense remains so

The San Francisco 49ers and Arizona Cardinals will meet on Sunday at State Farm Stadium. Here's who experts think will win the Week 11 battle.

Key 49ers and Cardinals offensive stars face critical tests as both teams battle to regain momentum and establish dominance.

With these two crucial weapons back on the gridiron, 49ers fans will have to like their team's chances this weekend. The 49ers and Cardinals are set to clash on Sunday at 4:05 PM EST – San Francisco earned a 16-15 victory in their first meeting this season.

Nov 9, 2025; Santa Clara, California, USA; San Francisco 49ers running back Christian McCaffrey (23) walks on the field prior to the game against the Los Angeles Rams at Levi's Stadium. Mandatory Credit: Cary Edmondson-Imagn Images / Cary Edmondson-Imagn Images ARIZONA -- The Arizona Cardinals' next test doesn't get any easier to pass.

NFC West standings: Rams, Seahawks strengthen records with wins over 49ers, Cardinals originally appeared on The Sporting News. Add The Sporting News as a Preferred Source by clicking here. The NFC West has proven to be the most difficult division in the NFL this year with three teams in playoff positioning entering Sunday.

The Cardinals are hurting badly on offense, meaning a suspect 49ers defense might have things a bit easier in their Week 11 NFC West showdown.

After six weeks of patiently waiting for Brock Purdy to recover from a second turf toe injury, it seems the 49ers plan to start him this upcoming Sunday against