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The playoff-eliminated San Francisco 49ers are set to host the Detroit Lions on Monday night in a rematch of last season's ...

The Miami Dolphins inched closer to finishing their season with a winning record by beating the San Francisco 49ers a week ...

Few, if any, NFL franchises can match the history, success, and overall talent of the San Francisco 49ers. Tied with the Dallas Cowboys for the third-most Super Bowl wins in NFL history with five, the ...

San Francisco 49ers top scorers look to capitalize on opportunities early against Detroit Lions stout defense.

For Lions defensive coordinator Aaron Glenn's money, 49ers star George Kittle is the best tight end in football.

Less than a year ago, the 49ers and the Lions were the two best teams in the NFC. Now the Lions are on the verge of locking up the no. 1 seed.

San Francisco 49ers face a daunting Week 17 test against Detroit Lions with injuries threatening their ability to compete.

San Francisco 49ers tight end George Kittle has recorded three games with at least 100 receiving yards this season, the most ...

A California appeals court has overturned the rape conviction of former San Francisco 49er Dana Stubblefield after ...

The San Francisco 49ers face slim odds of landing a top-nine pick in the 2025 NFL Draft. The Carolina Panthers and New York ...

The Detroit Lions and the San Francisco 49ers will go head to head for Monday Night Football this week, but tight end George Kittle is kicking things off with nothing but love, at least as it relates ...