Facing a remarkable chance to remain in the playoff race until the final week of the season, the Colts instead came out flat, mistake-prone and overmatched against the NFL's worst team, dropping a 45-33 decision to a woeful New York Giants team that had lost its last 10 games and seemed destined for the No. 1 pick in the NFL draft.

There was some major shakeup at the top of the 2025 NFL Draft order in Week 17. The New York Giants, who controlled their own destiny to secure the No. 1 pick, put up 45 points to upset the Indianapolis Colts.