The 49ers were without three of their top playmakers for much of the matchup, with running back Christian McCaffrey (Achilles) and wide receivers Brandon Aiyuk (knee) and Deebo Samuel (illness) all sidelined by the end of the day. Their final touchdown, a sneak by Purdy, came with under two minutes to play.

A lot has changed for both teams since their overtime thriller in Las Vegas, including significant injuries. Our beat writers break it down.