Background Most mental health disorders are first experienced during childhood. There are evidence-based treatments, but it ...

Introduction A substantial number of patients with major depressive disorder experience non-remission despite treatment with psychotherapy and several antidepressant drugs. This has increased the ...

Introduction The number of people living with dementia is increasing worldwide. Alzheimer’s disease (AD) is the most common type of dementia. It typically manifests itself initially with cognitive ...

Introduction Stress is a major health issue in contemporary society, and mindfulness-based approaches reduce stress and anxiety but face practical barriers to consistent practice; this protocol ...

Introduction Programmes based on early childhood development (ECD) services play a vital role in improving child health and developmental outcomes. Across many countries, these programmes target ...

Objectives This study aims to compare early mortality after total knee arthroplasty (TKA) using conventional intramedullary instrumentation to TKA performed using technology-assisted ...

1 Department of Neurosurgery, Academic Medical Center, Neurosurgical Center Amsterdam, Amsterdam, The Netherlands 2 Department of Neurosurgery, Leiden University Medical Center, Leiden, The ...

Objectives Evidence comparing the effectiveness of surgical and conservative treatment of symptomatic lumbar disc herniation is controversial. We sought to compare short-term and long-term ...