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This video down the Alpha-1 receptor signaling cascade step-by-step: α1 Receptor → Gq → PLC → IP3 + DAG → ↑ Ca²⁺ → MLCK Activation → Smooth Muscle Contraction Key clinical effects: • Vasoconstriction • ↑ Blood Pressure • Mydriasis • Urinary Retention Major locations: • Vascular smooth muscle • Iris (radial muscle ...
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